January 17, 2012

Question bank on General Pharmacology


For students of 2nd Prof. MBBS

Pharmacokinetics

1. Definition of Drug. Difference between drug and medicine.
2. Different routes of drug administration, their advantages and disadvantages, examples of each route.
3. Define Pharmacokinetics. How does it differ from Pharmacodynamics?
4. Write short notes on:
a) Passive transport of drugs
b) Absorption of drug
c) Plasma protein binding of drug and its significance
d) Apparent volume of distribution and its significance. Why is it called “apparent”?
e) Blood brain barrier and its pharmacological significance
f) Biotransformation and its two phases
g) Microsomal enzymes, their inducers and inhibitors
h) Cytochrome P-450
i) Bioavailibility of a drug, Calculation, Significance
j) Half life of a drug, types, calculation, significance
k) Clearence and its pharmacological significance
l) Steady state plasma concentration of a drug

Pharmacodynamics and adverse drug reaction

1. Define pharmacodynamics.
2. Mechanisms of drug action.
3. Define: Agonist, antagonist and partial agonist. What is Inverse agonist?
4. Short notes on:
a) Therapeutic Index
b) Therapeutic window
c) Tolerance
d) Tachyphylaxis
e) Effects of drug combinations
f) Types of antagonism
g) Pharmacogenetics
h) Teratogenic drugs
i) Side effect vs. Secondary effects
j) Idiosyncrasy
k) P-drugs
l) Essential drugs
m) Orphan drugs

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